Nate Wells, an artist known for his work on System Shock 2, discussed the artistic choices that contributed to the game's unsettling atmosphere, particularly the design of the alien entity The Many. The Many is characterized by a grotesque, biological aesthetic, contrasting with the sterile corridors of the game. An unexpected source of inspiration for the textures of The Many came from colonoscopy imagery, which influenced the design of the sphincter doors. Wells noted the glistening, veiny appearance of these elements and acknowledged the remastered version's distinct puckered quality. His creative process aimed to balance fear with a sense of playfulness, contributing to the game's lasting appeal.