In Vampire: The Masquerade – Bloodlines 2, players can only save their progress through an auto-save system that activates at certain checkpoints, marked by Anarch Tags. Quitting the game does not trigger a save, and players are warned that exiting to the main menu will result in the loss of unsaved progress. The game has only one auto-save slot, which is overwritten when starting a new playthrough, though previous saves are preserved in a file starting from a checkpoint. Players can access a chapter select option by choosing 'Load Game' at the title screen, allowing them to start from completed quests, with a total of 22 unique saves available for those who have finished the game. Selecting a quest will overwrite the current auto-save.