Microsoft has informed the business community about a known issue with Message Queuing (MSMQ) affecting enterprise applications and Internet Information Services (IIS) sites. This problem primarily impacts users on Windows 10 22H2, Windows Server 2019, and Windows Server 2016 who installed specific security updates (KB5071546, KB5071544, and KB5071543) released in December 2025. Symptoms include inactive MSMQ queues, applications unable to write to queues, IIS sites failing with "insufficient resources" errors, and misleading messages about disk space or memory. The issue stems from changes to the MSMQ security model that altered permissions on the C:WindowsSystem32MSMQstorage folder, requiring MSMQ users to have write access to a directory typically restricted to administrators. Microsoft has not provided a timeline for a fix and suggests affected IT administrators contact their support team for temporary workarounds or consider rolling back the updates.