Microsoft has introduced native NVMe support in Windows Server 2025, enhancing the performance of modern NVMe devices, including PCIe Gen5 SSDs and high-end Host Bus Adapters (HBAs). This feature eliminates the translation layers that previously routed NVMe I/O through SCSI, resulting in reduced processing overhead and latency. Testing shows that Windows Server 2025 can achieve up to 80% higher 4K random read IOPS and approximately 45% fewer CPU cycles per I/O compared to Windows Server 2022. The enhancements benefit enterprise applications such as SQL Server, OLTP workloads, and virtualization environments using Hyper-V, as well as analytics and AI/ML workloads. To utilize native NVMe, system administrators must use the in-box Windows NVMe driver, and the feature requires an opt-in process with the latest cumulative update and registry key or Group Policy configuration. Organizations should validate the implementation to assess its impact on their production environments.