Resident Evil: Requiem features a mod called the Enemies Scale Modifier, created by modder lucablight83, which allows players to adjust enemy sizes, making them smaller or larger, thus adding humor to the horror gameplay. This mod requires the installation of the RE Framework and enables players to scale enemies down to 10% or up to 300% of their original size. It introduces comedic elements while maintaining gameplay challenges, such as aiming at miniaturized foes. Additionally, there are other mods available that enhance the game with humorous elements, like transforming Leon's Porsche into a driveable hamburger, or introduce serious challenges, such as zombie bites that infect players. A VR mod is also available for an immersive experience.