Windows 2000 can run on modern hardware using a setup that includes a Gigabyte H410 H V2 motherboard, a 10th Gen Intel Core i5 processor, and a Super GPU from 2006. The Universal NT Installer, a Linux-based tool, allows for the installation of Windows NT versions, including Windows 2000. The system can boot from an NVMe SSD and recognizes all 12 CPU cores, achieving transfer speeds of 2500MB/s. However, there are challenges such as inconsistent HDMI audio support and some USB 3 drives not functioning properly.