Slay the Spire 2 sold 3 million copies within a week of its launch and players completed 25 million runs, with the developer suggesting the actual number may be higher. The game topped the Steam sales charts and retains familiar gameplay elements. Future updates will include Steam Workshop support, a new scoring system, and a phobia accessibility mode. An expansion for the Slay the Spire board game, titled Downfall, is set to launch on March 24.