The protagonist, humorously named "Dr. Doctor Eadful," operates in a Lovecraftian world where he faces challenges in his unconventional medical practice. A mishap with a patient named Victor Harlow triggers a series of unfortunate events. Players engage in narrative adventure and light puzzles, diagnosing patients based on the four humours and administering treatments, which become increasingly complex. Incorrect treatments can lead to severe consequences, including patients worsening or dying, impacting the doctor's reputation and financial stability. The protagonist is pressured to make ethically questionable decisions, including accepting a proposition from a gravedigger to misadminister treatments for profit. The game explores the tension between ethical medical practice and survival, leading to a descent into madness.