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Zero-day exploits are attacks that take advantage of previously unknown software vulnerabilities before a vendor can issue a patch. These exploits pose significant challenges because organizations cannot address vulnerabilities they are unaware of, and traditional security measures may not effectively identify them. Zero-day vulnerabilities are distinct from zero-day exploits; the former refers to the software flaw itself, while the latter is the method used by attackers to exploit that flaw. Zero-day exploits are particularly dangerous because they give attackers a temporary advantage, allowing them to compromise systems before defenders can respond. These exploits are commonly used in advanced attacks, including ransomware campaigns and espionage. The lifecycle of a zero-day exploit typically involves discovering a vulnerability, weaponizing it, delivering the exploit, executing malicious code, and achieving the attacker's objectives. Traditional antivirus solutions may not consistently prevent zero-day exploits, as they primarily focus on known threats. Endpoint Detection and Response (EDR) platforms provide visibility and detection but do not inherently prevent exploitation. Effective prevention strategies emphasize stopping the exploitation techniques themselves, rather than solely relying on detection. Memory-based attack prevention is a key approach, as all exploits must execute within memory. This method disrupts exploitation techniques and can protect against unknown vulnerabilities. Best practices for preventing zero-day exploits include reducing the attack surface, enforcing least privilege, maintaining aggressive patch management, strengthening identity security, deploying prevention-based endpoint protection, and maintaining a layered security strategy.