The Apothecary Diaries features Maomao, a young female alchemist in the Forbidden Palace, who becomes an unofficial forensic pathologist solving court mysteries. A new video game titled The Apothecary Diaries: The False Imperial Brother is set to be released in early 2027, where players will assist Maomao in investigating the "Five Mysteries and Five Curses" involving a masked figure known as the 'imperial younger brother.' The gameplay includes clue-gathering, dialogue puzzles, and a deduction phase requiring players to present evidence. The game is conceptualized by the manga series author Hyuganatsu, aiming to maintain the essence of the anime while providing an interactive experience. Fans express concerns about preserving Maomao's character integrity amidst potential branching narratives.