Vampire Crawlers builds on the mechanics of its predecessor, Vampire Survivors, allowing players to collect and deploy cards with reduced cognitive load during battles. The game features a synergy system that enhances damage output through strategic card selection and mana management. Combat consists of fast-paced waves of enemies, and players can utilize a Play All feature for automation, which can be effective if they have a strong deck. The game is currently featured in the Steam Deckbuilders Fest event.